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Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

โœ Scribed by Kruger, B.; Krick, S.; Dhillon, N.; Lerner, S. M.; Ames, S.; Bromberg, J. S.; Lin, M.; Walsh, L.; Vella, J.; Fischereder, M.; Kramer, B. K.; Colvin, R. B.; Heeger, P. S.; Murphy, B. T.; Schroppel, B.


Book ID
121852649
Publisher
National Academy of Sciences
Year
2009
Tongue
English
Weight
897 KB
Volume
106
Category
Article
ISSN
0027-8424

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This study analyzes how toll-like receptor 4 (TLR4) signaling in the donor organ affects the ischemia and reperfusion injury (IRI) sequel following liver transplantation. Isogenic orthotopic liver transplantations (OLTs) with rearterialization were performed in groups of wild-type (WT) and TLR4 knoc