This study investigates the tolerability, safety and efficacy of abrupt or stepwise switching from donepezil to memantine treatment in patients with moderate-to-severe Alzheimer's disease (AD). Outpatients (Table 1), !50 years, with dementia of the Alzheimer's type (DSM-IV-TR), MMSE 18 and receiving
Donepezil in patients with severe alzheimer’s disease
✍ Scribed by Karen Marder
- Book ID
- 107545902
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 61 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1528-4042
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## Abstract ## Background There have been very limited investigations of cholinesterase inhibitor therapy in more advanced stages of Alzheimer's disease (AD). The efficacy and safety of donepezil were evaluated in __post hoc__ analyses of a subgroup of patients with more severe AD (standardized Mi
## Background: Current outcome measures for alzheimer's disease (ad) drugs have been criticized as insufficiently patient-centred. one commonly unmeasured goal of patients and caregivers is verbal repetition. ## Objectives: We examined how often reducing repetition (of questions, statements or st