Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease
✍ Scribed by Howard, Robert; McShane, Rupert; Lindesay, James; Ritchie, Craig; Baldwin, Ashley; Barber, Robert; Burns, Alistair; Dening, Tom; Findlay, David; Holmes, Clive
- Book ID
- 111887339
- Publisher
- Massachusetts Medical Society
- Year
- 2012
- Tongue
- English
- Weight
- 676 KB
- Volume
- 366
- Category
- Article
- ISSN
- 0096-6762
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📜 SIMILAR VOLUMES
## Abstract ## Background Alzheimer's disease (AD) is the leading cause of dementia and its course renders patients functionally disabled. Memantine is the first drug to demonstrate a clinical benefit in the treatment of patients with moderately‐severe to severe AD. ## Objectives Our objective w
This study investigates the tolerability, safety and efficacy of abrupt or stepwise switching from donepezil to memantine treatment in patients with moderate-to-severe Alzheimer's disease (AD). Outpatients (Table 1), !50 years, with dementia of the Alzheimer's type (DSM-IV-TR), MMSE 18 and receiving