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Domoic acid as a developmental neurotoxin

โœ Scribed by Lucio G. Costa; Gennaro Giordano; Elaine M. Faustman


Book ID
116780175
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
300 KB
Volume
31
Category
Article
ISSN
0161-813X

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Domoic acid induces a time-dependent neuroexcitotoxic effect in neonatal rats characterized by hyperactivity, stereotypic scratching, convulsions, and death with observable behaviors occurring at exposures 40 times lower by body weight in neonates than reported in adults. Low doses of domoic acid (0