Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure o
โฆ LIBER โฆ
Dominant rearrangements among human tumor-infiltrating lymphocytes. Analysis of T-cells derived from 32 patients with melanoma, lung, and renal cell carcinoma
โ Scribed by William T. Bennett; Franco Pandolfi; Beverly H. Grove; Gail E. Hawes; Lenora A. Boyle; Richard L. Kradin; James T. Kurnick
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 614 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0008-543X
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## Renal-cell carcinoma (RCC ) is one of the human cancers which respond best to immunotherapy. To better characterize the mechanism of the immune response in RCC, we analyzed the T-cell receptor (TCR) p-chain repertoire in primary RCC, metastases and paired peripheral blood lymphocytes (PBL) from