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Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

✍ Scribed by Minegishi, Yoshiyuki; Saito, Masako; Tsuchiya, Shigeru; Tsuge, Ikuya; Takada, Hidetoshi; Hara, Toshiro; Kawamura, Nobuaki; Ariga, Tadashi; Pasic, Srdjan; Stojkovic, Oliver


Book ID
109896891
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
586 KB
Volume
448
Category
Article
ISSN
0028-0836

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## Abstract The EWS‐Oct‐4 protein is a chimeric molecule in which the amino terminal domain (NTD) of the EWS becomes fused to the carboxy terminal domain (CTD) of the Oct‐4 transcription factor. It was identified in human bone and soft‐tissue tumors associated with t(6;22)(p21;q12). Using __in vitr