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Dominant lethal studies in male mice after exposure to a 50-Hz electric field

✍ Scribed by C. I. Kowalczuk; R. D. Saunders

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 504 KB
Volume: 11
Category: Article
ISSN: 0197-8462
DOI: 10.1002/bem.2250110204

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Male C3H/He mice were sham‐exposed or exposed continuously for 2 weeks to a vertical, 50‐Hz, electric field at 20 kV/m rms. Densities of currents induced in the testes are estimated to be near 100 μA/m^2^. After the exposure, each male was mated with two different female mice each week during a period of 8 weeks. By this schedule, female mice were impregnated with sperm that had been exposed to the electric field at different stages of the spermatogenic cycle. No significant differences as a function of exposure condition were observed in pregnancy rates or in survival of embryos before or after implantation. The absence of effects was not due to insensitivity of assays; other mice that were exposed to X‐rays (dose to testes = 1.5 Gy) presented reliable evidence of mutagenesis.

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