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Dolutegravir: A Next-Generation Integrase Inhibitor for Treatment of HIV Infection

โœ Scribed by Osterholzer, D. A.; Goldman, M.

Book ID
121812240
Publisher
University of Chicago Press
Year
2014
Tongue
English
Weight
435 KB
Volume
59
Category
Article
ISSN
1058-4838

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โœ Victor Hadi; Yung-Hyo Koh; Tino Wilson Sanchez; Danielle Barrios; Nouri Neamati; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 522 KB

HIV-1 integrase (IN), one of the essential enzymes in HIV infection, has been validated as a target for HIV treatment. While more than 20 drugs have been approved by the FDA to treat HIV/AIDS, only one drug, Raltegravir (1), was approved as an IN inhibitor. The rapid mutation of the virus, which lea