𝔖 Bobbio Scriptorium
✦   LIBER   ✦

DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma

✍ Scribed by Nael Al-sarraf; Johanne Nørvig Reiff; Jane Hinrichsen; Shaukat Mahmood; Bin Tean Teh; Eilish McGovern; Pierre De Meyts; Kenneth J. O'Byrne; Steven G. Gray

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
543 KB
Volume
121
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The insulin‐receptor substrate family plays important roles in cellular growth, signaling, and survival. We have previously shown the dysregulation of the IGF‐axis in clear cell renal cell carcinoma. In this manuscript, we examine the expression of the insulin receptor substrate family in clear cell RCC, and demonstrate that the expression of 2 members of this family are significantly altered in tumors. The most striking finding is that expression of the new IRS family member IRS‐5 is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The PTEN regulator DJ-1 is associated wi
The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma
✍ Raviprakash T. Sitaram; Claire J. Cairney; Pawel Grabowski; W. Nicol Keith; Beng 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 354 KB 👁 1 views

## Abstract DJ‐1 is as a novel regulator of the tumor suppressor PTEN with stimulatory effects on PI3K‐AKT/PKB signaling, one possible target of which is cMyc. The catalytic unit of the telomerase complex, hTERT, can be activated at different levels, including transcriptionally by cMyc and through

Human agmatinase is diminished in the cl
Human agmatinase is diminished in the clear cell type of renal cell carcinoma
✍ Kerstin Dallmann; Heike Junker; Stefan Balabanov; Uwe Zimmermann; Jürgen Giebel; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 299 KB

## Abstract The proteome of RCC was analyzed by 2D PAGE to search for tumor‐associated proteins. Agmatinase, which hydrolyzes agmatine to putrescine and urea, was identified by mass spectrometry and database searches and shown to be downregulated in tumor cells. Additionally, RT‐PCR and Northern bl

Osteopontin expression correlates with p
Osteopontin expression correlates with prognostic variables and survival in clear cell renal cell carcinoma
✍ Koviljka Matusan; Gordana Dordevic; Darko Stipic; Vladimir Mozetic; Ksenija Luci 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

## Abstract ## Background and Objectives Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including tumorigenesis and tumor cell metastasis. Recently, it has been detected in a growing number of human tumors, and assessed as a potential prognostic marker. The aim of this s

Aberrations of a cell adhesion molecule
Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma
✍ Masayoshi Nagata; Mika Sakurai-Yageta; Daisuke Yamada; Akiteru Goto; Akihiko Ito 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 874 KB

## Abstract Renal clear cell carcinoma (RCCC) is the most frequent subpopulation of renal cell carcinoma and is derived from the proximal uriniferous tubules. We have previously reported that an actin‐binding protein, 4.1B/DAL‐1, is expressed in renal proximal tubules, whereas it is inactivated in