The possibility and conditions for the induction of porphyrin synthesis by exogenous S-aminolaevulinic acid (ALA) and its applicability for the inactivation of Gram-negative bacteria Escherichiu coli R. by photodynamic therapy (PDT) have been studied. The bacteria are supplemented with ALA i n the l
Does δ-aminolaevulinic acid induce genotoxic effects?
✍ Scribed by Dagmar M. Fiedler; Peter M. Eckl; Barbara Krammer
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 675 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1011-1344
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Human adenocarcinoma cells of the line WiDr have been treated with 2 mM 5-aminolaevulinic acid (5-ALA) in the presence of 10% foetal calf serum. The treatment induces a linear accumulation of protoporphyrin IX (PpIX) for at least 7.5 h. After 7.5 h of incubation about 45% of the PpIX accumulated is