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Does tolerance develop to levodopa? Comparison of 2-and 21-h levodopa infusions

✍ Scribed by Dr. John G. Nutt; Julie H. Carter; William Woodward; John P. Hammerstad; Stephen T. Gancher

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 452 KB
Volume: 8
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870080204

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To determine if acute tolerance to levodopa develops, we compared the response to 2‐ and 21‐h levodopa infusions with the rate adjusted during the long infusion to yield the same plasma concentration as at the end of the 2‐h infusion. The duration of response after discontinuing the long infusions was briefer than after discontinuing the short infusion, suggesting the development of tolerance. Furthermore, dyskinesia severity was greater during long infusions. We conclude that continuous dopaminergic stimulation with levodopa may not offer optimal control of parkinsonism in patients with response fluctuations.

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