Does the PCPA induced anticonflict effect involve activation of the GABAA/benzodiazepine chloride ionophore receptor complex?

Effect of thiol group modification on io

Effect of thiol group modification on ion flux and ligand binding properties of the GABAA-benzodiazepine receptor chloride channel complex

✍ A. M. Allan; L. D. Baier 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

Agents that modify thiol groups have been shown to alter ligand binding at a variety of receptor sites. In addition, alkylation of sulfhydryls has been shown to block ion channel conductance. We studied the effects of thiol reagents on y-aminobutyric acid (GABA)-activated chloride flux (36Cl-) and [