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Does the p75 neurotrophin receptor mediate Aβ-induced toxicity in Alzheimer's disease?

✍ Scribed by Elizabeth J. Coulson

Book ID
111179597
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
143 KB
Volume
98
Category
Article
ISSN
0022-3042

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✍ Emi Tsukamoto; Yuichi Hashimoto; Kohsuke Kanekura; Takako Niikura; Sadakazu Aiso 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 379 KB

## Abstract Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid‐β peptides (Aβ). Aβ binding to the 75‐kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Aβ causes cell death in neuronal hybrid cells transf