Does the central nervous system play a role in vitamin D deficiency-related chronic pain?

Different tumors in bone each give rise

Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system

✍ Mary Ann C. Sabino; Nancy M. Luger; David B. Mach; Scott D. Rogers; Matthew J. S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 371 KB

Pain is the most common presenting symptom in patients with bone cancer and bone cancer pain can be both debilitating and difficult to control fully. To begin to understand the mechanisms involved in the generation and maintenance of bone cancer pain, we implanted 3 well-described murine tumor cell