DOES THE BCR/ABL-MEDIATED INCREASE IN THE EFFICACY OF DNA REPAIR PLAY A ROLE IN THE DRUG RESISTANCE OF CANCER CELLS?

The vitamin D receptor-mediated activati

The vitamin D receptor-mediated activation of phosphatidylinositol 3-kinase (PI3Kα) plays a role in the 1α,25-dihydroxyvitamin D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines

✍ Philip J. Hughes; Jimmy S. Lee; Neil E. Reiner; Geoffrey Brown 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

## Abstract In this article we show that 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) stimulates the activity of the class IA phosphatidylinositol 3‐kinase PI3Kα and its downstream target Akt in HL60, U937 and THP‐1 myeloid leukaemic cell lines. Furthermore, we show that the classical nuclear vit