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Does P-glycoprotein play a role in anticancer drug pharmacokinetics?

✍ Scribed by Alex Sparreboom; Kees Nooter

Book ID
117836177
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
232 KB
Volume
3
Category
Article
ISSN
1368-7646

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Digoxin and beta-methyldigoxin were evaluated pharmacokinetically in terms of P-glycoprotein (P-gp)-mediated drug interactions in rats. Evaluation was made by measuring the effects of a potent P-gp inhibitor (verapamil, cyclosporin A) on in vitro efflux transport of these compounds across the everte