✦ LIBER ✦

Does obstructive jaundice adversely affect wound healing?

✍ Scribed by M. G. Greaney; R. Van Noort; A. Smythe; T. T. Irvin

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 358 KB
Volume: 66
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800660708

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✦ Synopsis

Summary

The effect of obstructive jaundice on wound healing has been investigated in an experimental study of abdominal wounds in rats following ligation and division of the common bile duct. Animals were jaundiced for 2 weeks before a second operation at which the abdominal wounds were made. The wounds in jaundiced and control animals showed no significant differences in mechanical strength during a 21-day period of study but there was a significant delay in the accumulation of collagen in the wounds of jaundiced animals. The findings suggest that the biochemical changes in the wounds of jaundiced animals did not interfere with wound repair and cast doubt on the thesis that jaundice has an adverse effect on wound healing.

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