Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?
โ Scribed by Chen, Weimin; Jiang, Tao; Wang, Huihui; Tao, Shasha; Lau, Alexandria; Fang, Deyu; Zhang, Donna D.
- Book ID
- 115486244
- Publisher
- Mary Ann Liebert
- Year
- 2012
- Tongue
- English
- Weight
- 455 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1523-0864
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Although the Bclโ2 family members and p53 are involved in the regulation of apoptosis, the status of apoptotic machinery (eg caspases) plays a major role in determining the mode and timing of cell death. If the apoptotic machinery is lost, inhibited, or intrinsically inactivated, the โd
p53 plays a critical role as a tumour-suppressor in restricting the proliferation of damaged cells, thus preventing formation of genetically altered cell clones. Its inactivation leads, in particular, to accumulation of polyploid and aneuploid cells. To elucidate the role of p53 in control of chromo