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Does nonsense-mediated mRNA decay explain the ovarian cancer cluster region of the BRCA2 gene?

✍ Scribed by Ware, M D; DeSilva, D; Sinilnikova, O M; Stoppa-Lyonnet, D; Tavtigian, S V; Mazoyer, S

Book ID
110070068
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
188 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract Frameshift mutations at coding mononucleotide repeats (cMNR) are frequent in high‐microsatellite instability (MSI‐H) cancers. Frameshift mutations in cMNR result in the formation of a premature termination codon (PTC) in the transcribed mRNA, and these abnormal mRNAs are generally degra