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Does modafinil enhance activity of patients with myotonic dystrophy?

✍ Scribed by A.R. Wintzen; G.J. Lammers; J.G. van Dijk

Book ID
106093306
Publisher
Springer
Year
2007
Tongue
English
Weight
93 KB
Volume
254
Category
Article
ISSN
0340-5354

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We tested the hypothesis that the instability of the trinucleotide CTG at the myotonic dystrophy (DM) locus could be an intrinsic DNA damage recognisable by the p53 cell-cycle checkpoint system. p53 mRNA and protein levels were assayed in muscle biopsies and fibroblast cell lines of DM patients and