Background: Infliximab (IFX) treatment induces mucosal healing (MH) in patients with Crohn's disease (CD) but the impact of MH on the long-term outcome of IFX treatment in CD is still debated. ## Methods: We studied MH during long-term treatment with IFX in 214 CD patients. A total of 183 patients
Does methotrexate induce mucosal healing in Crohn's disease?
✍ Scribed by Míriam Mañosa; Juan E. Naves; Carles Leal; Eduard Cabré; Vicente Moreno; Vicente Lorenzo-Zuñiga; Jaume Boix; Eugeni Domènech
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 54 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1078-0998
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A number of disease-specific instruments have been created over the last 30 years to assess disease activity in Crohn's disease (CD). These disease activity indices are constituted of clinical and laboratory parameters and their role in predicting disease activity and the course of disease has been
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## Background: In the two benchmark controlled trials in Crohn's disease (CD) supporting its use, methotrexate (MTX) was used as the immunosuppressant of choice in immunomodulatory-naive patients. However, in daily clinical practice MTX is used generally after thiopurine analogs have failed. ## Me