✦ LIBER ✦

Does a patient qualify for liver transplantation after the down-staging of hepatocellular carcinoma?

✍ Scribed by Francis Y. Yao; Stefan Breitenstein; Christoph E. Broelsch; Jean-Francois Dufour; Morris Sherman

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 96 KB
Volume: 17
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.22335

No coin nor oath required. For personal study only.

✦ Synopsis

We searched the MEDLINE database (PubMed) and the Cochrane Library to identify studies evaluating down-staging and locoregional therapy for hepatocellular carcinoma (HCC) before liver transplantation (LT). The search was restricted to studies written in English and published from 1995 to 2010. The key words for the search included down-staging, liver transplantation, hepatocellular carcinoma, locoregional therapy, staging, treatment outcomes, radio frequency ablation, and transarterial chemoembolization. All published articles and abstracts were reviewed and screened by 2 members of the working group independently (F.Y.Y. and S.B.), and relevant articles and abstracts were selected for further review by the group. The group agreed on 5 key questions for addressing this topic, and each of the 5

📜 SIMILAR VOLUMES

Down-staging of hepatocellular carcinoma

Down-staging of hepatocellular carcinoma prior to liver transplantation: The power of selection

✍ Matteo Ravaioli; Gian Luca Grazi; Matteo Cescon; Franco Trevisani; Fabio Piscagl 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 44 KB 👁 1 views

We enjoyed the article by Yao et al. in the recent issue of HEPATOL-OGY 1 in which they report an excellent outcome of liver transplantation (LT) following preoperative down-staging of hepatocellular carcinoma (HCC). Yao et al. selected HCCs without vascular invasion by imaging studies and out of t

Liver transplantation outcomes for early

Liver transplantation outcomes for early-stage hepatocellular carcinoma: Results of a multicenter study

✍ Jessica Y. Leung; Andrew X. Zhu; Fredric D. Gordon; Daniel S. Pratt; Abigail Mit 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

The incidence of hepatocellular carcinoma (HCC), a frequent and incurable complication of cirrhosis, continues to rise. Orthotopic liver transplantation (OLT) has been proposed as a treatment for unresectable, intrahepatic HCC limited in extent to the Milan criteria adopted by the United Network of

Tools for monitoring patients with hepat

Tools for monitoring patients with hepatocellular carcinoma on the waiting list and after liver transplantation

✍ Norman Kneteman; Tito Livraghi; David Madoff; Eduardo de Santibañez; Michael Kew 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

For patients who are initially being listed for liver transplantation and for patients who are seeking to retain their active status on the wait list, the first step in the diagnostic consideration of hepatocellular carcinoma (HCC) is the accurate identification and staging of the tumors. Advances i

What is the best staging system for hepa

What is the best staging system for hepatocellular carcinoma in the setting of liver transplantation?

✍ Kim M. Olthoff; Alejandro Forner; Stefan Hübscher; John Fung 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB 👁 1 views

The purposes of cancer staging are (1) to accurately predict a patient's prognosis and (2) to determine the appropriate interventions. Hepatocellular carcinoma (HCC) is somewhat unique: it usually affects patients with underlying liver disease, and both tumor burden and liver function need to be car

Optimizing staging for hepatocellular ca

Optimizing staging for hepatocellular carcinoma before liver transplantation: A retrospective analysis of the UNOS/OPTN database

✍ Richard B. Freeman; Abigail Mithoefer; Robin Ruthazer; Khanh Nguyen; Anthony Sch 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB 👁 1 views

Assignment of liver allocation priority for hepatocellular carcinoma is predicated on accurate imaging staging. We analyzed radiographically defined stage (radiologic stage [RS]) at listing and most recent extension and pathologic stage (PS) data from 789 liver transplant recipients for whom no pret

A new priority policy for patients with

A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system

✍ Fabio Piscaglia; Valeria Camaggi; Matteo Ravaioli; Gian Luca Grazi; Matteo Zanel 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB 👁 1 views

The best prioritization of patients with hepatocellular carcinoma (HCC) waiting for liver transplantation under the model for end-stage liver disease (MELD) allocation system is still being debated. We analyzed the impact of a MELD adjustment for HCC, which consisted of the addition of an extra scor