Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? : A prospective cohort study and a nested case–control family study of older women

✍ Scribed by Janet E. Olson; Thomas A. Sellers; Kristin E. Anderson; Aaron R. Folsom

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 72 KB
• Volume: 85
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990601)85:11<2444::aid-cncr20>3.0.co;2-m

✦ Synopsis

BACKGROUND.

As part of the hereditary nonpolyposis colon carcinoma (HNPCC) constellation of neoplasia caused by defects in mismatch repair genes, some endometrial carcinomas are known to have a genetic contribution to etiology.

However, most endometrial carcinomas occur in postmenopausal women, presumably without the HNPCC defect. Consequently, the genetic contribution to these cases is unclear. The objective of this study was to determine whether family history of cancer is a risk factor for endometrial carcinoma in older women.