Docosahexaenoic acid (omega − 3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells

Estrogen and non-genomic upregulation of

Estrogen and non-genomic upregulation of voltage-gated Na+ channel activity in MDA-MB-231 human breast cancer cells: Role in adhesion

✍ Scott P. Fraser; Iley Ozerlat-Gunduz; Rustem Onkal; James K.J. Diss; David S. La 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

## Abstract External (but not internal) application of β‐estradiol (E2) increased the current amplitude of voltage‐gated Na^+^ channels (VGSCs) in MDA‐MB‐231 human breast cancer (BCa) cells. The G‐protein activator GTP‐γ‐S, by itself, also increased the VGSC current whilst the G‐protein inhibitor G

Docosahexaenoic acid (omega&#xa0;−&#xa0;3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells

Docosahexaenoic acid (omega − 3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells