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Docking study and binding free energy calculation of poly (ADP-ribose) polymerase inhibitors

โœ Scribed by Kazuki Ohno; Takashi Mitsui; Yoshiaki Tanida; Azuma Matsuura; Hideaki Fujitani; Tatsuya Niimi; Masaya Orita


Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
227 KB
Volume
17
Category
Article
ISSN
1610-2940

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Binding kinetics and activity of human p
โœ Timothy J. Jorgensen; Kevin Chen; Sergey Chasovskikh; Rabindra Roy; Anatoly Drit ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 314 KB

## Abstract Poly(ADPโ€ribose) polymeraseโ€1 (PARPโ€1) is a mammalian enzyme that attaches long branching chains of ADPโ€ribose to specific nuclear proteins, including itself. Because its activity __in vitro__ is dependent upon interaction with broken DNA, it has been postulated that PARPโ€1 plays an imp