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DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

✍ Scribed by Teresa Lambe; Greg Crawford; Andy L. Johnson; Tanya L. Crockford; Tiphaine Bouriez-Jones; Aisling M. Smyth; Trung H. M. Pham; Qian Zhang; Alexandra F. Freeman; Jason G. Cyster; Helen C. Su; Richard J. Cornall

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
685 KB
Volume
41
Category
Article
ISSN
0014-2980

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Memory T cell responses are frequently highly restricted in terms of receptor usage. How and when such clonotypic dominance is established remains poorly understood. Here we have investigated the evolution of the T cell responses to an epitope from Epstein-Barr virus (EBV), (FLRGRAYGL), by analyzing