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Do RARA/PML fusion gene deletions confer resistance to ATRA-based therapy in patients with acute promyelocytic leukemia?

✍ Scribed by Subramaniyam, S; Nandula, S V; Nichols, G; Weiner, M; Satwani, P; Alobeid, B; Bhagat, G; Murty, V V

Book ID
110056922
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
166 KB
Volume
20
Category
Article
ISSN
0887-6924

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In vitro response to all-trans retinoic
In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes
✍ Marie-Joëlle Mozziconacci; Concetta Liberatore; Véronique Brunel; Francesco Grig 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 941 KB

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) cytogenetic abnormality leading to the expression of two fusion genes, PML/RARA and RARA/PML, and by its sensitivity to all-trans retinoic acid (ATRA) differentiating treatment. Rare APL cases lacking the t(15;17) have been describe