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Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs

โœ Scribed by Brian Meldrum


Book ID
108460377
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
95 KB
Volume
50
Category
Article
ISSN
0920-1211

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Effects of conventional antiepileptic dr
โœ J.P. Leite; E.A. Cavalheiro ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 831 KB

Pilocarpine (PILO) induces in rats limbic seizures that become secondarily generalized and evolve to status epilepticus (SE). Spontaneous recurrent seizures are registered during the long-term period following the systemic administration of PILO in rats. EEG, behavioral, and pathological features re