## Abstract Rare germline variants in mismatch repair genes have been linked to hereditary nonpolyposis colorectal cancer; however, it is unknown whether common polymorphisms in these genes alter the risk of colorectal cancer. To examine the association between common variants in mismatch repair ge
โฆ LIBER โฆ
Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?
โ Scribed by E. Tulupova; R. Kumar; M. Hanova; J. Slyskova; B. Pardini; V. Polakova; A. Naccarati; L. Vodickova; J. Novotny; J. Halamkova; K. Hemminki; P. Vodicka
- Book ID
- 113809219
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 194 KB
- Volume
- 648
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Rare inherited mutations in the __mutL homolog 1__ (__MLH1__) DNA mismatch repair gene can confer an increased susceptibility to colorectal cancer (CRC) with high penetrance where disease frequently develops in the proximal colon. The core promoter of __MLH1__ contains a common single n
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