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Do Phthalates Affect Steroidogenesis by the Human Fetal Testis? Exposure of Human Fetal Testis Xenografts to Di-n-Butyl Phthalate

✍ Scribed by Mitchell, R. T.; Childs, A. J.; Anderson, R. A.; van den Driesche, S.; Saunders, P. T. K.; McKinnell, C.; Wallace, W. H. B.; Kelnar, C. J. H.; Sharpe, R. M.


Book ID
127393447
Publisher
Endocrine Society
Year
2012
Tongue
English
Weight
698 KB
Volume
97
Category
Article
ISSN
0021-972X

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## Abstract Adult male rats gestationally exposed to di(n‐butyl)phthalate (DBP) have dysgenetic testes characterized by seminiferous epithelial degeneration, clustering of Leydig cells, and decreased spermatogenesis. Cell proliferation and apoptosis are key processes regulating development of the t