## Abstract The gene coding for urokinase‐plasminogen activator (PLAU) is a strong biological and positional candidate gene for Alzheimer's disease (AD). Previously some studies have examined the role of common variation in the PLAU gene with AD risk but the results have been inconsistent and this
Do personality traits predict the occurrence of Alzheimer's disease?
✍ Scribed by Wolfgang Meins; Jörg Dammast
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 80 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0885-6230
No coin nor oath required. For personal study only.
✦ Synopsis
Objective. To identify speci®c premorbid personality traits in patients with Alzheimer's disease (AD). Design. A prospective case-control study. Setting. A memory clinic of a department of geriatric medicine in a teaching hospital. Patients. Fifty-six consecutive patients with probable AD. Sixty-®ve controls with Parkinson's disease (PD). Measures. Premorbid personality traits were assessed using the relative rating version of the Munich Personality Test (MPT).
Results. The AD patients showed higher neuroticism than the controls with PD ( p 0.013). In comparison with MPT normative values for psychiatric inpatients, the AD patients scored signi®cantly ( p 5 0.05) lower on neuroticism and higher on frustration tolerance and rigidity.
Conclusion. Our results support the assumption of speci®c premorbid characteristics in AD patients, ie increased neuroticism and rigidity. More research is needed to con®rm the existence of typical premorbid personality traits in AD.
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