Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy

Aromatic hydroxylation of phenylalanine

Aromatic hydroxylation of phenylalanine as an assay for hydroxyl radicals: Application to activated human neutrophils and to the heme protein leghemoglobin

✍ Harparkash Kaur; Ingrid Fagerheim; Martin Grootveld; Alain Puppo; Barry Halliwel 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 650 KB

Attack of hydroxyl radical (.OH), generated by a Fenton system at physiological pH, upon L-phenylalanine produces three isomeric tyrosines, o-tyrosine (2-hydroxyphenylalanine), m-tyrosine (3-hydroxyphenylalanine), and p-tyrosine (4-hydroxyphenylalanine). These may be separated by high-performance li