Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?

✍ Scribed by M. L. de Ceballos; M. Baker; S. Rose; P. Jenner; Professor C. D. Marsden

• Book ID: 102947116
• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 861 KB
• Volume: 1
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870010402

✦ Synopsis

Thermal injury (30-s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met-and leu-enkephalin content in the penaqueductal grey (PAC)