Do animal models of anxiety predict anxiolytic-like effects of antidepressants?
β Scribed by Franco Borsini; Jana Podhorna; Donatella Marazziti
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 169 KB
- Volume
- 163
- Category
- Article
- ISSN
- 0033-3158
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π SIMILAR VOLUMES
Effects of intracerebroventircular (ICV), neuropeptide Y (NPY) (0.2-5.0 nmol) and its C-terminal 13-36 amino acid (AA) fragment (0.4~2.0 nmol) have been examined with respect to anxiolytic properties in two rat anxiety models, Montgomery's conflict test (MT), and Vogel's drinking conflict test (VT).
We have examined the anxiolytic activity of acute and chronic antidepressant treatment in an animal model of anxiety involving novelty-suppressed feeding. Rats were food deprived for 48 h, placed into a novel environment containing food, and the latency to begin eating was recorded. Chronic (21 days