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DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8

✍ Scribed by Satoshi Kurita; Hajime Higuchi; Yoshimasa Saito; Nobuhiro Nakamoto; Hiromasa Takaishi; Shinichiro Tada; Hidetsugu Saito; Gregory J. Gores; Toshifumi Hibi

Book ID
108586729
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
539 KB
Volume
101
Category
Article
ISSN
1347-9032

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Quercetin sensitizes human hepatoma cell
Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation
✍ Jin Yeop Kim; Eun Hee Kim; Seok Soon Park; Jun Hee Lim; Taeg Kyu Kwon; Kyeong So 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB

## Abstract This study demonstrates that combined treatment with subtoxic doses of quercetin (3′,3′,4′,5,7‐pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces rapid apoptosis in TRAIL‐resistant hepatocel