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DNG1, aDictyosteliumhomologue of tumor suppressor ING1 regulates differentiation ofDictyosteliumcells

✍ Scribed by T. Mayanagi; A. Amagai; Y. Maeda

Book ID
105758076
Publisher
Springer
Year
2005
Tongue
English
Weight
570 KB
Volume
62
Category
Article
ISSN
1420-682X

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The candidate tumor-suppressor gene ING1 encodes p33 ING1 , a nuclear protein which physically interacts with TP53. It has been shown that p33 ING1 acts in the same biochemical pathway as TP53, leading to cell growth inhibition. Interestingly, a rearrangement of the ING1 gene was found in a neurobla