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DNA vaccines: Vector design, delivery, and antigen presentation

✍ Scribed by David M. Feltquate

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
66 KB
Volume
72
Category
Article
ISSN
0730-2312

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✦ Synopsis

Inoculations with antigen-expressing plasmid DNAs (DNA vaccines) in the production of protective immune responses. Since the initial development of DNA vaccines more than 5 years ago, major strides have been made in the design of efficient vaccine vectors and in the process of vaccine delivery. However, many questions remain regarding the mechanism of cellular transfection and in the development of immune responses. This review addresses functional aspects of DNA vaccines, including vector design and delivery, as well as cellular transfection and antigen presentation.

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