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DNA vaccines encoding retrovirus-based virus-like particles induce efficient immune responses without adjuvant

✍ Scribed by Bertrand Bellier; Charlotte Dalba; Béatrice Clerc; Delphine Desjardins; Rosybel Drury; François-Loïc Cosset; Mary Collins; David Klatzmann


Book ID
116958587
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
450 KB
Volume
24
Category
Article
ISSN
0264-410X

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Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8 + or CD4 + T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and