DNA Topology in Heterochromatin (a Hypothesis)

✍ Scribed by ALEXEY D. GRUZDEV

• Book ID: 102612686
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 161 KB
• Volume: 207
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.2000.2170

✦ Synopsis

A hypothesis explaining the known heterochromatin features*a compact DNA packaging, transcriptional inactivity, propensity to aggregate (stickiness) and position e!ect variegation*is described. The hypothesis is based on the assumption that DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with identical or similar primary sequences.