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DNA topoisomerase II alpha: a favorable prognostic factor in colorectal caner

✍ Scribed by Xian Hua Gao; Zhi Qi Yu; Chang Zhang; Chen Guang Bai; Jian Ming Zheng; Chuan Gang Fu

Book ID: 113036922
Publisher: Springer
Year: 2011
Tongue: English
Weight: 305 KB
Volume: 27
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s00384-011-1346-x

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## BACKGROUND. The DNA topoisomerase II-alpha (topo II-alpha)-targeting drug etoposide was recently shown to be an active agent in the combined chemotherapy of hormoneinsensitive prostatic carcinoma. Aside from being the molecular target of etoposide, topo II-alpha is also a cell proliferation mark