DNA synthesis in mammalian nuclei: Inhibition of DNA synthesis in the resting rat liver nucleus by ethidium bromide, proflavin and actinomycin D
β Scribed by M.Anwar Waqar; Leigh A. Burgoyne
- Book ID
- 118852696
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- English
- Weight
- 326 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Aflatoxin is a potent hepatocarcinogen. Biochemically the shortβterm action which seems to be the most important is an inhibition of nucleic acid synthesis. Injection of low doses (from 500 to 1,000 ΞΌg/kg) made it possible to modulate the different inhibitions induced by aflatoxin. The
## Abstract Colchicine inhibited the initiation of DNA synthesis by hepatocytes in vivo and by WIβ38 and C3H10T 1/2 cells in vitro. All three cell types were most sensitive to colchicine when it was administered at the time of, or shortly after, proliferative activation (by partial hepatectomy or m