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DNA strand scission and PC12 cell death induced by salsolinol and copper

โœ Scribed by Hyun-Jung Kim; Hye-Ran Yoon; Stacy Washington; In I Chang; Young J Oh; Young-Joon Surh

Book ID
117475944
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
88 KB
Volume
238
Category
Article
ISSN
0304-3940

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DNA and RNA strand scission by copper, z
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โœ W. Karol Dowjat; Malkhaz Kharatishvili; Max Costa ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 626 KB

Copper/zinc (Cu/ZnSOD) and manganese (MnSOD) superoxide dismutases which catalyze the dismutation of toxic superoxide anion, O(2-)-, to O2 and H2O2, play a major role in protecting cells from toxicity of oxidative stress. However, cells overexpressing either form of the enzyme show signs of toxicity