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DNA single-strand breaks induced by 3 cross-linking agents

✍ Scribed by N. Yajima; S. Hochi; T. Kishi; G. Kawanishi

Book ID
113251595
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
84 KB
Volume
203
Category
Article
ISSN
0165-1161

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Methylglyoxal (MG) , a dietary mutagen, is present in various frequently consumed beverages and foods and in cigarette smoke. A combination of S, nuclease hydrolysis and alkaline unwinding assay was used to demonstrate the formation of single-strand breaks and interstrand cross-links in DNA upon tr