DNA sequencing by CE
✍ Scribed by Barry L. Karger; András Guttman
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 346 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0173-0835
No coin nor oath required. For personal study only.
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## Contents Capillary electrophoresis has been under development for DNA sequencing since 1990. This development has traveled down two parallel tracks. The first track studied the details of DNA separation by gel electrophoresis. Early work stressed rapid separations at high electric fields, which
## Abstract We show that the fine oscillatory structure of the DNA melting curve can be used to determine explicitly the nucleotide composition and the order of certain domains within the DNA. If DNA is specifically fragmented, the order of fragments can be learned directly from a comparison of the