DNA sequences specific for Caucasian G3m(b) and (g) allotypes: allotyping at the genomic level

Deletion of hinge region of human myelom

Deletion of hinge region of human myeloma lgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes. A possible genetic explanation at the DNA level

✍ C. Rivat; Liliane Rivat; C. Ropartz; Claudine Schiff; M. Fougereau 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 795 KB

## Abstract In this paper we report the structural basis for the nonexpression of G1m(3) and Km(1, 2) allotypes in an IgG1 (__K__) human myeloma protein (protein LEC). Heavy and light chains spontaneously dissociate in sodium dodecyl sulfate polyacrylamide gels. Light chains appear to be covalently