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DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

✍ Scribed by Nickerson, Deborah A.; Taylor, Scott L.; Weiss, Kenneth M.; Clark, Andrew G.; Hutchinson, Richard G.; Stengård, Jari; Salomaa, Veikko; Vartiainen, Erkki; Boerwinkle, Eric; Sing, Charles F.

Book ID
109832007
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
394 KB
Volume
19
Category
Article
ISSN
1061-4036

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Lipoprotein lipase (LPL) plays a central role in the metabolism of lipoproteins by hydrolyzing the core triglycerides of circulating very low density lipoproteins and chylomicrons. The enzyme is encoded by a gene about 30kb in size located on the short arm of human chromosome 8. We have determined t