## Abstract In higher eukaryotic cells, DNA is tandemly arranged into 10^4^ replicons that are replicated once per cell cycle during the S phase. To achieve this, DNA is organized into loops attached to the nuclear matrix. Each loop represents one individual replicon with the origin of replication
DNA replication occurs at the nuclear matrix
✍ Scribed by C. Sellke; X. Hanhua; W. H. Strätling; L. Phi-van
- Book ID
- 115144079
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 284 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0931-2668
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## Abstract It is still unclear what nuclear components support initiation of DNA replication. To address this issue, we developed a cell‐free replication system in which the nuclear matrix along with the residual matrix‐attached chromatin was used as a substrate for DNA replication. We found out t
## Abstract The mammalian sperm nucleus provides an excellent model for studying the relationship between the formation of nuclear structure and the initiation of DNA replication. We previously demonstrated that mammalian sperm nuclei contain a nuclear matrix that organizes the DNA into loop domain