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DNA repair in antibody somatic hypermutation

โœ Scribed by Paolo Casali; Zsuzsanna Pal; Zhenming Xu; Hong Zan


Book ID
116577769
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
219 KB
Volume
27
Category
Article
ISSN
1471-4906

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Somatic hypermutation: subverted DNA rep
โœ Stella A Martomo; Patricia J Gearhart ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 255 KB

Somatic hypermutation generates high-affinity antibodies of different isotypes that efficiently protect us against a plethora of pathogens. Recent analyses of the types of mutations produced in gene-deficient mice have indicated how DNA repair proteins are drawn into the pathway. Activation-induced