𝔖 Bobbio Scriptorium
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DNA Repair, H-2, and Aging in NZB and CBA Mice

✍ Scribed by Kathleen Y. Hall; Kathy Bergmann; Roy L. Walford


Book ID
115093179
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
421 KB
Volume
17
Category
Article
ISSN
0001-2815

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performed to determine whether endogenous lymphoid tissue concentrations of prostaglandins also vary as a function of age, sex, and genetic susceptibility to autoimmunc disease.

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One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in __XPD__ , a gene encoding a DNA helicase that functions in both repair and transcription and that is mutate