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DNA repair genes BRCA1 and DNA-PKcs have great potential in radiation therapy

✍ Scribed by Yang, Jiao; Xu, Ximing; Hao, Yanrong

Book ID
118793484
Publisher
Springer
Year
2012
Tongue
English
Weight
218 KB
Volume
11
Category
Article
ISSN
1610-1979

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## Abstract Mutations of BRCA1 gene are associated with more than half the cases of hereditary breast cancer. Breast cancer formation in BRCA1 mutation carriers is generally accompanied by loss of the wild‐type allele, suggesting that BRCA1 protein may function as a tumor suppressor. The human BRCA